The UnExplainer - MEN 1 or Wermer Syndrome 1. Parathyroid hyperplasia (~80%) 2. Pituitary adenoma (~66%) 3. Pancreatic tumours (e.g. Gastrinoma [50%], insulinoma) Gene =MEN1 gene, menin protein (tumour suppressor) MEN 2a
![The 27 MEN1 gene mutations found in 100 apparently sporadic pancreatic... | Download Scientific Diagram The 27 MEN1 gene mutations found in 100 apparently sporadic pancreatic... | Download Scientific Diagram](https://www.researchgate.net/publication/44691053/figure/fig3/AS:667677701992452@1536198177392/The-27-MEN1-gene-mutations-found-in-100-apparently-sporadic-pancreatic-endocrine-tumors.jpg)
The 27 MEN1 gene mutations found in 100 apparently sporadic pancreatic... | Download Scientific Diagram
![Current and emerging therapies for PNETs in patients with or without MEN1 | Nature Reviews Endocrinology Current and emerging therapies for PNETs in patients with or without MEN1 | Nature Reviews Endocrinology](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fnrendo.2018.3/MediaObjects/41574_2018_Article_BFnrendo20183_Fig1_HTML.jpg)
Current and emerging therapies for PNETs in patients with or without MEN1 | Nature Reviews Endocrinology
![Endocrines | Free Full-Text | Involvement of the MEN1 Gene in Hormone-Related Cancers: Clues from Molecular Studies, Mouse Models, and Patient Investigations Endocrines | Free Full-Text | Involvement of the MEN1 Gene in Hormone-Related Cancers: Clues from Molecular Studies, Mouse Models, and Patient Investigations](https://www.mdpi.com/endocrines/endocrines-01-00007/article_deploy/html/images/endocrines-01-00007-g002.png)
Endocrines | Free Full-Text | Involvement of the MEN1 Gene in Hormone-Related Cancers: Clues from Molecular Studies, Mouse Models, and Patient Investigations
![A) Schematic representation of MEN1 gene. Rectangles represents MEN1... | Download Scientific Diagram A) Schematic representation of MEN1 gene. Rectangles represents MEN1... | Download Scientific Diagram](https://www.researchgate.net/publication/369101037/figure/fig3/AS:11431281172876382@1688682329395/A-Schematic-representation-of-MEN1-gene-Rectangles-represents-MEN1-exons-numbered-from.png)
A) Schematic representation of MEN1 gene. Rectangles represents MEN1... | Download Scientific Diagram
![Endocrines | Free Full-Text | Involvement of the MEN1 Gene in Hormone-Related Cancers: Clues from Molecular Studies, Mouse Models, and Patient Investigations Endocrines | Free Full-Text | Involvement of the MEN1 Gene in Hormone-Related Cancers: Clues from Molecular Studies, Mouse Models, and Patient Investigations](https://pub.mdpi-res.com/endocrines/endocrines-01-00007/article_deploy/html/images/endocrines-01-00007-g001.png?1601528941)
Endocrines | Free Full-Text | Involvement of the MEN1 Gene in Hormone-Related Cancers: Clues from Molecular Studies, Mouse Models, and Patient Investigations
![❗NTE®️N🅰️L Ⓜ️edℹ©️ℹne on X: "Genetic endocrine syndrome Multiple endocrine neoplasia MEN1==》3️⃣🅿️s MEN2A==》2️⃣🅿️s MEN2B==》1️⃣🅿️ #FOAMed #MedTwitter #MedEd https://t.co/ttbv9NM7Mp" / X ❗NTE®️N🅰️L Ⓜ️edℹ©️ℹne on X: "Genetic endocrine syndrome Multiple endocrine neoplasia MEN1==》3️⃣🅿️s MEN2A==》2️⃣🅿️s MEN2B==》1️⃣🅿️ #FOAMed #MedTwitter #MedEd https://t.co/ttbv9NM7Mp" / X](https://pbs.twimg.com/media/FWWNogMXoAEyUO6.jpg)
❗NTE®️N🅰️L Ⓜ️edℹ©️ℹne on X: "Genetic endocrine syndrome Multiple endocrine neoplasia MEN1==》3️⃣🅿️s MEN2A==》2️⃣🅿️s MEN2B==》1️⃣🅿️ #FOAMed #MedTwitter #MedEd https://t.co/ttbv9NM7Mp" / X
![PDF] Tissue selectivity in multiple endocrine neoplasia type 1-associated tumorigenesis. | Semantic Scholar PDF] Tissue selectivity in multiple endocrine neoplasia type 1-associated tumorigenesis. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/16f415084f68cc8796886831c62d110ad7ceb2f3/2-Figure1-1.png)
PDF] Tissue selectivity in multiple endocrine neoplasia type 1-associated tumorigenesis. | Semantic Scholar
![MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases in: Endocrine-Related Cancer Volume 17 Issue 3 (2010) MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases in: Endocrine-Related Cancer Volume 17 Issue 3 (2010)](https://erc.bioscientifica.com/view/journals/erc/17/3/images/large/771fig1.jpeg)
MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases in: Endocrine-Related Cancer Volume 17 Issue 3 (2010)
![Genetics of Endocrine and Neuroendocrine Neoplasias (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf Genetics of Endocrine and Neuroendocrine Neoplasias (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf](https://www.ncbi.nlm.nih.gov/books/NBK65830/bin/CDR0000749983.jpg)
Genetics of Endocrine and Neuroendocrine Neoplasias (PDQ®) - PDQ Cancer Information Summaries - NCBI Bookshelf
![Distinct clinical phenotypes in a family with a novel truncating MEN1 frameshift mutation | BMC Endocrine Disorders | Full Text Distinct clinical phenotypes in a family with a novel truncating MEN1 frameshift mutation | BMC Endocrine Disorders | Full Text](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs12902-022-00978-9/MediaObjects/12902_2022_978_Fig2_HTML.png)
Distinct clinical phenotypes in a family with a novel truncating MEN1 frameshift mutation | BMC Endocrine Disorders | Full Text
![MEN1 gene and its mutations: Basic and clinical implications - Tsukada - 2009 - Cancer Science - Wiley Online Library MEN1 gene and its mutations: Basic and clinical implications - Tsukada - 2009 - Cancer Science - Wiley Online Library](https://onlinelibrary.wiley.com/cms/asset/221b47ed-43d2-4464-beaf-73598b01bfb6/cas_1034_f2.gif)
MEN1 gene and its mutations: Basic and clinical implications - Tsukada - 2009 - Cancer Science - Wiley Online Library
![Figure 1 from MEN1 gene mutation analysis in Italian patients with multiple endocrine neoplasia type 1. | Semantic Scholar Figure 1 from MEN1 gene mutation analysis in Italian patients with multiple endocrine neoplasia type 1. | Semantic Scholar](https://d3i71xaburhd42.cloudfront.net/b5148b4e2fdf753553faecb41d9b2c4ecab361f5/4-Figure1-1.png)
Figure 1 from MEN1 gene mutation analysis in Italian patients with multiple endocrine neoplasia type 1. | Semantic Scholar
![A Box of Chemistry to Inhibit the MEN1 Tumor Suppressor Gene Promoting Leukemia - Ozyerli‐Goknar - 2021 - ChemMedChem - Wiley Online Library A Box of Chemistry to Inhibit the MEN1 Tumor Suppressor Gene Promoting Leukemia - Ozyerli‐Goknar - 2021 - ChemMedChem - Wiley Online Library](https://chemistry-europe.onlinelibrary.wiley.com/cms/asset/d061a60d-b3e1-432b-9416-c851e9f69396/cmdc202000972-fig-0001-m.jpg)